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Prime 95B is the Scientific CMOS with extreme sensitivity using high Quantum Efficiency (QE) Backside Illumination (BSI), a first for Scientific CMOS cameras. The 95B’s sensor converts up to 95% of incident photons into a measurable signal. Unlike microlens approaches to increasing QE, which lose effectiveness as objective magnification is increased, Prime 95B’s BSI sensor brings light into the pixel photodiode from behind, avoiding structures that reflect or absorb light. When combined with large 11μm pixels, Prime 95B can deliver over 300% more signal than other sCMOS cameras at 100X magnification.

More importantly, Prime 95B outperforms EMCCD cameras—with no excess noise that negates the benefit of using a high QE sensor, and additional limitations from EM gain calibration, stability, expense, and sensor lifetime With a true 16-bit dynamic range, Prime 95B easily accomplishes what EMCCD can not—detect weak and bright signals within the same image with photon-noise limited performance. 

The extreme sensitivity not only allows fainter signals to be detected, it provides the flexibility to increase frame rates, or turn down the excitation intensity to reduce cellular photo-damage. Yet Prime 95B maintains the same high frame rates, field-of-view and extremely low read noise that has made sCMOS so popular for live-cell imaging.




Prime BSI delivers the perfect balance between high resolution imaging and sensitivity with an optimized pixel design and near perfect 95% Quantum Efficiency to maximize signal detection. A 4 Megapixel camera with 6.5μm pixels, it captures highly detailed images with great quality while acquiring data at high frame rates. This ensures that all data is collected and no event goes undetected. 

Prime BSI delivers a 100% pixel fill factor and does not rely on micro-lensing technology to increase detection, resulting in a 30% increase in sensitivity over previous sCMOS cameras.

With the near-perfect sensitivity of Backside Illuminated Scientific CMOS sensors, the latest generation of scientific cameras have enabled imaging using only a few photons per pixel. Unfortunately, these minute signals are dominated by the natural Poisson variation in light levels preventing useful quantitation. PrimeEnhance uses a quantitative SNR enhancement algorithm used in Life Science imaging to reduce the impact of photon shot-noise present in acquired images, leading to an increase in Signal to Noise Ratio (SNR) by 3x to 5x with equivalent exposure times. With PrimeEnhance, the exposure times can be reduced by a factor of 8-10X while maintaining the Signal to Noise ratio. This reduces the effects of cellular photo-damage and extends cell lifetimes.




Iris 9 Scientific CMOS camera is designed to deliver extremely high-resolution images for live cell microscopy applications. Iris 9 delivers a 9 Megapixel sensor with a 17.8mm field of view ensuring it can maximize the number of cells captured in a single frame.

The 4.25µm pixels provide highly detailed images across the imaging plane and allow for Nyquist spatial sampling at 40X magnification. The camera can capture dynamic cellular events at 30 frames per second for the full frame, and at thousands of frames per second with regions.

The Iris 9 has a high quantum efficiency and low noise levels to maximize dim signal detection and allowing for the use of shorter exposure times to minimize cellular photo-damage. The Iris 9 is the ideal camera to deliver high resolution images at high frame rates for live-cell microscopy applications



Prime BSI delivers the perfect balance between high resolution imaging and sensitivity with an optimized pixel design and near perfect 95% Quantum Efficiency to maximize signal detection. A 4 Megapixel camera with 6.5μm pixels, it captures highly detailed images with great quality while acquiring data at high frame rates. This ensures that all data is collected and no event goes undetected. 

Prime BSI delivers a 100% pixel fill factor and does not rely on micro-lensing technology to increase detection, resulting in a 30% increase in sensitivity over previous sCMOS cameras.

With the near-perfect sensitivity of Backside Illuminated Scientific CMOS sensors, the latest generation of scientific cameras have enabled imaging using only a few photons per pixel. Unfortunately, these minute signals are dominated by the natural Poisson variation in light levels preventing useful quantitation. PrimeEnhance uses a quantitative SNR enhancement algorithm used in Life Science imaging to reduce the impact of photon shot-noise present in acquired images, leading to an increase in Signal to Noise Ratio (SNR) by 3x to 5x with equivalent exposure times. With PrimeEnhance, the exposure times can be reduced by a factor of 8-10X while maintaining the Signal to Noise ratio. This reduces the effects of cellular photo-damage and extends cell lifetimes.




Iris 9 Scientific CMOS camera is designed to deliver extremely high-resolution images for live cell microscopy applications. Iris 9 delivers a 9 Megapixel sensor with a 17.8mm field of view ensuring it can maximize the number of cells captured in a single frame.

The 4.25µm pixels provide highly detailed images across the imaging plane and allow for Nyquist spatial sampling at 40X magnification. The camera can capture dynamic cellular events at 30 frames per second for the full frame, and at thousands of frames per second with regions.

The Iris 9 has a high quantum efficiency and low noise levels to maximize dim signal detection and allowing for the use of shorter exposure times to minimize cellular photo-damage. The Iris 9 is the ideal camera to deliver high resolution images at high frame rates for live-cell microscopy applications


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